|CAS No.: 1811-31-0||Request for quotation|
N-acetylgalactosamine is the least known of the eight essential sugars. As with the others, this one is also important for proper cell-to-cell communication. This communication is important for both normal systemic function and in such disease processes as cancer, inflammation, and immunity.
It appears that N-acetylgalactosamine is absorbed from the intestines by a specific transporter, but more research needs to be done on this. As it stands now, there appears to be a specific transporter for this saccharide that differs from that used by Glucose. Researchers are just beginning to realize the existence of specific intestinal cell transporters for all the different essential sugars.
There is little specific data available, but it appears that N-acetylgalactosamine is excreted in much the same way as the other glyconutrients; that is, in the urine, since a specific enzyme for this saccharide is located in the kidney and could be used for recycling the sugar. Studies indicate that most of an oral dose would be eliminated from the bloodstream after 8-12 hours.
Since research is fairly new for this particular sugar, little is known for sure. During lab experiments, exceptionally high doses are used. Therefore, to equate a safe dose for humans at this time is pure speculation. What is known is that when extremely high doses of N-acetylgalactosamine are given to experimental animals, a type of hepatitis is created. It is speculated that as much as 280 mg. twice a day would be safe for a healthy 150-pound adult. Information is not available as to a minimum amount. As with other essential sugars, whatever amount is taken should be divided into two daily doses to keep blood levels fairly constant.
|Appearance||A white or almost white, very hygroscopic powder or a fibrous aggregate||Standard Packing||100g/bag or per customer request|
|Assay (HPLC)||95.0-105.0%||Inventory||Normally we have N-Acetyl-D-galactosamine in stock|
|N-Acetyl-D-galactosamine physical parameters|
|Synonym||2-Acetamido-2-deoxy-D-galactose, D-GalNAc, N-Acetylchondrosamine|
|Certificate of Analysis||N-Acetyl-D-galactosamine COA|
|1.||Deepak Singodia et. al: Nanomedicine: Nanotechnology, Biology and Medicine, Volume 8, Issue 4, May 2012, Pages 468-477. Investigations into an alternate approach to target mannose receptors on macrophages using 4-sulfated N-acetyl galactosamine more efficiently in comparison with mannose-decorated liposomes: an application in drug delivery.|
|2.||Jianhao Feng, Chang-Chun Ling et.al: Carbohydrate Research, Volume 345, Issue 17, 22 November 2010, Pages 2450-2457. An efficient conversion of N-acetyl-d-glucosamine to N-acetyl-d-galactosamine and derivatives.|
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