Ascomycin

CAS No.: 104987-12-4   Request for quotation

Ascomycin is an ethyl analog of FK506 with strong immunosuppressant properties. Ascomycin acts by binding to immunophilins, especially macrophilin-12. It appears that Ascomycin inhibits the production of Th1 (interferon- and IL-2) and Th2 (IL-4 and IL-10) cytokines. Additionally, ascomycin preferentially inhibits the activation of mast cells, an important cellular component of the atopic response. Ascomycin produces a more selective immunomodulatory effect in that it inhibits the elicitation phase of allergic contact dermatitis but does not impair the primary immune response when administered systemically1. Ascomycin is purified from Streptomyces hygroscopicus var ascomyceticus.

Ascomycin Specification

Appearance Amorphous white powder   Standard Packing 10g/bag or per customer request
Purity (HPLC) 95%   Inventory Normally we have Ascomycin in stock
Total purity < 5%    
Melting point 156 - 161 °C   Ascomycin physical parameters
Heavy metal < 0.002%   CAS No: 104987-12-4
Water < 3.0%   Formula C43H69NO12
Total Isomer of Ascomycin < 5%   Molecular Weight 792.01
      Synonym FK520, FR 900520
      Solubility Soluble to 50 mM in DMSO and to 50 mM in ethanol
      Structure Ascomycin
       
       
       
         
Certificate of Analysis Ascomycin COA      
Literature Ascomycin literature      
MSDS Ascomycin MSDS      
         
References:  
1. Hatanaka et al (1988) FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physicochemical and biological characteristics. J.Antibiot (Tokyo). 41 1593.
2. Motamedi et al (1996) Characterization of methyltransferase and hydroxylase genes involved in the biosynthesis of the immunosuppressants FK506 and FK520. J.Bacteriol. 178 5243. PMID: 8752344.
3. Arndt et al (1999) Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans. Microbiology 145 1989. PMID: 10463165.
4. Revill et al (2002) Genetically engineered analogs of ascomycin for nerve regeneration. J.Pharmacol.Exp.Ther. 302 1278. PMID: 12183690.
 
.

Copyright © 2014. All Rights Reserved
Home >>
Ascomycin