Bilobalide A

CAS No.: 33570-04-6   Request for quotation

Bilobalide is a main constituent of the terpenoids found in Ginkgo leaves. It also exists in minor amounts in the roots. It is a sesquiterpenoid, i.e. It has also been discovered to inhibit the hypoxia-induced reduction of ATP and under normoxic conditions increase glucose transport. Bilobalide is a inhibitor of GABA Receptor and SR. Bilobalide is a activator of MB67. It has a 15-carbon skeleton. Its exact synthesis pathway from farnesyl pyrophosphate is still unknown.

Bilobalide is important for producing several of the effects of Gingko biloba extracts, and it has neuroprotective effects

Bilobalide A Specification (For research use only)

Appearance Yellow powder   Standard Packing 1g/bag or per customer request
Purity (HPLC) ≥ 95% or ≥ 97%   Inventory Normally we have Bilobalide A in stock
Loss on drying ≤ 3%    
Solubility: Soluble in ethanol(warm) (25 mg/ml), DMSO(warm) (25 mg/ml), and water (<1 mg/ml).   Bilobalide A physical parameters
      CAS No: 33570-04-6
      Formula C15H18O8
      Molecular Weight 326.30
      Synonym  
   
      Structure Bilobalide
     
     
     
     
   
         
Certificate of Analysis Bilobalide A COA  
Literature Bilobalide A literature  
MSDS Bilobalide A MSDS  
         
References:  
1. Bilobalid A, ein neues Sesquiterpen mit tert.-Butyl-Gruppe aus den Blättern von Ginkgo biloba L.: K. Weinges & W. Bähr; Liebigs Ann.Chem. 724,214 (1969)
2. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death: K. Chandrasekaran, et al.; Pharmacopsychiatry 36 Suppl 1 S89 (2003)
3. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons: F. Tchantchou, et al.; J. Alzheimers Dis. 18, 787 (2009)
4. Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats: Y. Taki, et al.; J. Pharmacol. Sci. 109, 459 (2009)
5. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells: C. Shi, et al.; Apoptosis 15, 715 (2010)
6. Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway: C. Shi, et al.; Neurochem. Int. 59, 59 (2011)
7. Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats: M. Goldie & S. Dolan; Behav. Pharmacol. 24, 298 (2013)
 
 

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Bilobalide A