Celastrol (Tripterin)

CAS No.: 34157-83-0   Request for quotation

Celastrol (tripterine) is a chemical compound isolated from the root extracts of Tripterygium wilfordii (Thunder god vine) and Celastrus regelii.

Celastrol is a pentacyclic triterpenoid and belongs in the family of quinone methides. In in vitro and in vivo animal experiments, celastrol exhibits antioxidant, anti-inflammatory, anticancer, and insecticidal activities. Its effects in humans have not been studied clinically.

Celastrol, an active component found in the Chinese herb tripterygium wilfordii has been identified as a neuroprotective agent for neurodegenerative diseases including Parkinson’s disease (PD) through unknown mechanism. Celastrol can induce autophagy, which plays a neuroprotective role in PD.

Celastrol (Tripterin) Specification (For research use only)

Appearance Red powder   Standard Packing 1g/bag or per customer request
Purity (HPLC) ≥ 97%   Inventory Normally we have Celastrol (Tripterin) in stock
Loss on drying      
Melting Point 219-230 °C   Celastrol (Tripterin) physical parameters
Solubility Soluble in DMSO (>10 mg/ml), ethanol, DMF:PBS(pH 7.2)(1:10), and DMF. Insoluble in water.   CAS No: 34157-83-0
      Formula C29H38O4
      Molecular Weight 450.61
      Synonym 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid, Tripterin
   
      Structure Celastrol
     
     
     
     
   
         
Certificate of Analysis Celastrol (Tripterin) COA  
Literature Celastrol (Tripterin) literature  
MSDS Celastrol (Tripterin) MSDS  
         
References:  
1. Upregulating Noxa by ER Stress, Celastrol Exerts Synergistic Anti-Cancer Activity in Combination with ABT-737 in Human Hepatocellular Carcinoma Cells.
2. Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. DOI: 10.1016/j.neuint.2013.04.005
3. Celastrol suppresses breast cancer MCF-7 cell viability via the AMP-activated protein kinase (AMPK)-induced p53–polo like kinase 2 (PLK-2) pathway. DOI: 10.1016/j.cellsig.2012.12.005
4. Celastrol significantly suppressed elevation of the renal function markers and the lipid peroxidation level, alleviated renal tubular damage, and decreased the levels of tumor necrosis factor-a, interleukin-1ß, and monocyte chemotactic protein-1 (MCP-1) messenger RNA in kidney caused by IR. Moreover, celastrol prevented IR-induced expression of pro-inflammatory mediators, which was associated with suppression of nuclear translocation of NF-?B subunit p65. DOI: 10.1016/j.jss.2013.07.048
5. Celastrol, an anti-cancer drug extracted from natural sources, induces inhibition of cell growth through modulation of ERa in estrogen positive breast cancer cells and is a candidate for use in cancer chemotherapy for human breast cancer. DOI: 10.1016/j.canlet.2010.09.006
6. Celastrol exhibits potent activity against CML cells bearing wild-type Bcr–Abl or -the T315I-mutant. DOI: 10.1016/j.canlet.2009.09.006
 
 

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Celastrol (Tripterin)