Epothilone D (synthetic)
Epothilone D Specification
Appearance | White Crystalline powder | Standard Packing | 50mg/bag or per customer request | |
Purity (HPLC) | ≥ 98% | Inventory | Normally we have Epothilone D in stock | |
Melting Point: | 63 - 66 ° | |||
Epothilone D physical parameters | ||||
CAS No: | 189453-10-9 | |||
Formula | C27H41NO5S | |||
Molecular Weight | 491.68 | |||
Synonym | (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; 12,13-Deoxyepothilone B; 12,13-Desoxyepothilone B; Desoxyepothilone B; Epo D; Epothilone D; KOS 862; NSC 703147; | |||
Solubility | ||||
Structure | ![]() |
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Certificate of Analysis | Epothilone D COA | |||
Literature | Epothilone D literature | |||
MSDS | Epothilone D MSDS | |||
References: | ||||
1. | Tack-Joong Kim et al: Vascular Pharmacology, 47(4) 2007, 229-237 "Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins" | |||
2. | Feng Sang et al: European Journal of Medicinal Chemistry, 68 (2013) 321-332 "Epothilone D and its 9-Methyl analogues: Combinatorial syntheses, conformation, and biological activities" | |||
3 | Robert L. Broadrup et al: Bioorganic Chemistry, 33(2) 2005 116–133. "Total synthesis of 12,13-desoxyepothilone B (Epothilone D)" | |||
4. | Alaksiej L.Hurski et al: Tetrahedron Letters 51(27) 2010,3497–3500 "Total synthesis of epothilone D by sixfold ring cleavage of cyclopropanol intermediates." | |||
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