N-Glycolylneuraminic acid

CAS No.: 1113-83-3   Request for quotation

N-Glycolylneuraminic acid (Neu5Gc) is an abundant sialic acid, occurring in the glycoconjugates of most deuterostome animals. Neu5Gc differs from Neu5Ac by an additional oxygen atom in the N-acyl moiety.

It is generally accepted that normal human tissues do not contain Neu5Gc. Interestingly, chickens also appear to lack Neu5Gc.

In cancer tissues,Neu5Gc is differentially expressed on gangliosides or glycoproteins.

N-Glycolylneuraminic acid Specification

Appearance White to off-white powder   Standard Packing 10g/bag or per customer request
Assay (HPLC) ≥ 95%   Inventory Normally we have N-Glycolylneuraminic acid in stock
Loss on drying ≤ 2.0%    
Lead ≤ 10 ppm   N-Glycolylneuraminic Acid physical parameters
Residue on Ignition ≤ 1.0%   CAS No: 1113-83-3
Melting Point 184 --186 ° C   Formula C11H19NO10
      Molecular Weight 325.57
      Synonym Neu5Glc, NeuNGl, Neu5Gc
      Structure N-Glycolylneuraminic Acid
     
     
     
     
         
Certificate of Analysis N-Glycolylneuraminic acid COA      
Literature N-Glycolylneuraminic acid literature      
MSDS N-Glycolylneuraminic acid MSDS      
         
References:  

1.

Nystedt, Anderson, Hirvonen et al.: STEM CELLS 2010; 28: 258-267. Human CMP-N-Acetylneuraminic Acid Hydroxylase Is a Novel Stem Cell Marker Linked to Stem Cell-Specific Mechanisms. Full text
2. Oliver M. T. Pearce, Ajit Varki et al.: Carbohydrate Research 345 (2010) 1225–1229. Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose
3. Igor O. Nasonkin et al.: Experimental Neurology 201 (2006) 525–529. Nonhuman sialic acid Neu5Gc is very low in human embryonic stem cell-derived neural precursors differentiated with B27/N2 and noggin: Implications for transplantation
 
 

Copyright © 2014. All Rights Reserved.
Home >>
N-Glycolylneuraminic acid