Nobiletin

CAS No.: 478-01-3   Request for quotation

Nobiletin is a polymethoxy flavonoid present in fruit tissues of citrus species and has been reported to suppress degranulation of RBL-2H3 cells.Nobiletin suppressed degranulation of both RBL-2H3 cells and bone marrow-derived mast cells induced by antigen stimulation. Nobiletin also suppressed degranulation stimulated by the calcium ionophore A23187 and thapsigargin, a specific inhibitor of the Ca2+-dependent ATPase.Some experiment show that nobiletin suppresses Ca2+ influx and consequently exerts the anti-allergy activity in a similar way to wortmannin.

Nobiletin reduced degranulation of RBL-2H3 cells and bone marrow-derived mast cells induced by antigen.
Nobiletin suppressed degranulation of RBL-2H3 cells induced by A23187 and thapsigargin.
Phosphorylation of PI3K and PLCγ1 was down-regulated by nobiletin.
Oral administration of nobiletin attenuated vascular permeability in PCA model mice.
Nobiletin suppressed allergic responses in a similar way to wortmannin.

Nobiletin Specification

Appearance White powder   Standard Packing 500g/bag or per customer request
Loss on drying ≤5%   Inventory Normally we have Nobiletin in stock
Residue on ignition ≤ 1%    
Heavy metals ≤ 10 ppm   Nobiletin physical parameters
Residual Solvent ≤ 0.05%   CAS No: 478-01-3
As ≤ 2 ppm   Formula C21H22O8
Assay ≥ 98%   Molecular Weight 402.39
      Synonym 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one, 3',4',5,6,7,8-Hexamethoxyflavone
      Structure Nobiletin
     
     
     
     
         
Certificate of Analysis Nobiletin COA      
Literature Nobiletin literature      
MSDS Nobiletin MSDS      
         
References:  
1. Nobiletin Attenuates VLDL Overproduction,Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance. This paper use our Nobiletin during their experiment. Full text
2. Nobiletin, a polymethoxy flavonoid, exerts anti-allergic effect by suppressing activation of phosphoinositide 3-kinase. DOI: 10.1016/j.jff.2013.12.005
   
 
 

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Nobiletin