Parthenolide
Parthenolide Specification
Appearance | White crystalline solid. | Standard Packing | 10g/bag or per customer request | |
Purity | > 98% | Inventory | Normally we have Parthenolide in stock | |
Melting point | 112°C-115°C | |||
UV spectrum | Most absporption peak observed @ 342nm, 359nm, 378nm, 397nm | Parthenolide physical parameters | ||
Solubility | Reportedly, maximum obtainable serum levels were 200 nM. DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane. |
CAS No: | 20554-84-1 | |
Formula | C15H20O3 | |||
Molecular Weight | 248.3 | |||
Synonym | Candeptin; Candimon; NSC 94219; Vanobid; | |||
Structure | ![]() |
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Certificate of Analysis | Parthenolide COA | |||
Literature | Parthenolide literature | |||
MSDS | Parthenolide MSDS | |||
References: | ||||
1. | Ralstin MC, et al: Mol Cancer Res. 2006 Jun;4(6):387-99 "Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest." | |||
2. | Lopez-Franco O et al: Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1864-70 "Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis." | |||
3. | Steele AJ, et al: Leukemia. 2006 Jun;20(6):1073-9. "The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro." | |||
4. | Tassorelli C,et al: Cephalalgia. 2005 Aug;25(8):612-21. "Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine." | |||
5. | Eri Takai, M.D. et al: Fertility and Sterility 100 (4) 2013,1170–1178 "Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model." | |||
6.. | Susan J. Zunino et al: Cancer Letters 254(1) 2007,119–127 "Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells." | |||
7. | Mazen Kurdi et al: Free Radical Biology and Medicine 42(4) 2007,474–481 "Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes." | |||
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