Parthenolide

CAS No.: 20554-84-1   Request for quotation

Parthenolide is a sesquiterpene lactone of the germacranolide class which occurs naturally in the plant feverfew (Tanacetum parthenium), after which it is named. It is found in highest concentration in the flowers and fruit.

Parthenolide repressed the development of endometriosis by suppressing the inflammatory peritoneal environment through the nuclear factor κB pathway.[5]

Parthenolide may have potential as a potent and novel therapeutic agent against pre-B ALLs.[6]

Parthenolide causes oxidative stress in cardiac myocytes by inducing superoxide formation by mitochondrial and NADPH oxidase in a dose-dependent manner. Parthenolide may be a useful tool for studying the roles of oxidative stress and mitochondrial dysfunction in the pathogenesis of cardiac hypertrophy and failure.[7]

Parthenolide Specification

Appearance White crystalline solid.   Standard Packing 10g/bag or per customer request
Purity > 98%   Inventory Normally we have Parthenolide in stock
Melting point 112°C-115°C    
UV spectrum Most absporption peak observed @ 342nm, 359nm, 378nm, 397nm   Parthenolide physical parameters
Solubility Reportedly, maximum obtainable serum levels were 200 nM.
DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.
  CAS No: 20554-84-1
Formula C15H20O3
      Molecular Weight 248.3
      Synonym Candeptin; Candimon; NSC 94219; Vanobid;
      Structure Parthenolide
         
 
 
Certificate of Analysis Parthenolide COA      
Literature Parthenolide literature      
MSDS Parthenolide MSDS      
         
References:  
1. Ralstin MC, et al: Mol Cancer Res. 2006 Jun;4(6):387-99 "Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest."
2. Lopez-Franco O et al: Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1864-70 "Parthenolide modulates the NF-kappaB-mediated inflammatory responses in experimental atherosclerosis."
3. Steele AJ, et al: Leukemia. 2006 Jun;20(6):1073-9. "The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro."
4. Tassorelli C,et al: Cephalalgia. 2005 Aug;25(8):612-21. "Parthenolide is the component of tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine."
5. Eri Takai, M.D. et al: Fertility and Sterility 100 (4) 2013,1170–1178 "Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model."
6.. Susan J. Zunino et al: Cancer Letters 254(1) 2007,119–127 "Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells."
7. Mazen Kurdi et al: Free Radical Biology and Medicine 42(4) 2007,474–481 "Parthenolide induces a distinct pattern of oxidative stress in cardiac myocytes."
 
 
 

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Parthenolide