|CAS No.: 53123-88-9||Our Rapamycin is GMP certificate and USP grade||Request for quotation|
|Rapamycin derivatives available - Click Here!|
Rapamycin (Sirolimus) Specification (USP)
|Appearance||Odorless, off-white to yellow crystalline powder||Standard Packing||100g/bag or per customer request|
|Purity (HPLC)||98%-102%||Inventory||Normally we have Rapamycin (Sirolimus), GMP certificate, USDMF in stock|
|Loss on drying||< 0.5%|
|Heavy metal||< 0.002%||Rapamycin (Sirolimus) physical parameters|
|Chromatographic purity||CAS No:||53123-88-9|
|Individual impurity||< 1%||Formula||C51H79NO13|
|Total impurity||< 2.0 %||Molecular Weight||914.17|
Cis-Stereoisomer of sirolimus
|Assay||98.0% to 102.0% calculated trans and cis-stereoismers of sirolimus on the dried basis||Structure|
|Residual Organic Solvents|
|Ethyl Acetate||≤5000 ppm|
|Petroleum Ether||≤1000 ppm|
Proper Use of RapamycinSirolimus usually comes with patient information or directions. Read them carefully and make sure you understand them before taking this medicine. If you have any questions, ask your health care professional.
Take Sirolimus only as directed by your doctor. Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Using too much will increase the risk of side effects, while using too little may lead to rejection of your transplanted kidney.
To help you remember to take your medicine, try to get into the habit of taking it at the same time each day. This will help sirolimus work better by keeping a constant amount in the blood.
Absorption of this medicine may be changed if you change your diet. This medicine should be taken consistently with respect to meals. You should not change the type or amount of food you eat unless you discuss it with your health care professional.
Do not stop taking this medicine without first checking with your doctor. You may have to take this medicine for the rest of your life to prevent your body from rejecting the transplant.
Sirolimus usually is used along with a corticosteroid (cortisone-like medicine) and cyclosporine (another immunosuppressive agent). Sirolimus should be taken 4 hours after cyclosporine modified oral solution (Neoral ) or cyclosporine modified capsules (Neoral). If you have any questions about this, ask your health care professional.
Mix sirolimus oral solution with at least 2 ounces (1/4 cup, 60 milliliters [mL]) of water or orange juice in a glass or plastic container. Stir the mixture well and drink it immediately. Then, rinse the container with at least 4 ounces (1/2 cup, 120 mL) of additional water or orange juice, stir it well, and drink it to make sure that all of the medicine is taken.
Check with your doctor before you stop using cyclosporine when you have been taking sirolimus together with cyclosporine for 4 months after your transplant. Your doctor will tell you if you need to keep taking cyclosporine.
The dose of sirolimus will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of sirolimus. If your dose is different, do not change it unless your doctor tells you to do so. If you have any questions about the proper dose of sirolimus, ask your doctor.
For oral dosage form (oral solution or tablets):
Missed dose of Rapamycin:
If you miss a dose of rapamycin and remember it within 12 hours, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose, go back to your regular dosing schedule, and check with your doctor. Do not double doses.
To store Rapamycin:
Keep out of the reach of children.
While you are taking sirolimus, it is important to maintain good dental hygiene and see a dentist regularly for teeth cleaning.
Raw oysters or other shellfish may contain bacteria that can cause serious illness and possibly death. This is more likely to be a problem if these foods are eaten by patients with certain medical conditions. Even eating oysters from “clean” water or good restaurants does not guarantee that the oysters do not contain the bacteria. Eating raw shellfish is not a problem for most healthy people; however, patients with the following conditions may be at greater risk: cancer, immune disorders, organ transplantation, long-term corticosteroid use (as for asthma, arthritis, or organ transplantation), liver disease (including viral hepatitis), excess alcohol intake (2 to 3 drinks or more per day), diabetes, stomach problems (including stomach surgery and low stomach acid), and hemochromatosis (an iron disorder). Do not eat raw oysters or other shellfish while you are taking sirolimus. Be sure oysters and shellfish are fully cooked.
While you are being treated with sirolimus, and after you stop treatment with it, it is important to see your doctor about the immunizations (vaccinations) you should receive. Do not get any immunizations without your doctor's approval. Sirolimus may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take or have recently taken oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid other persons who have taken the oral polio vaccine. Do not get close to them, and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.
Treatment with sirolimus may also increase the chance of getting other infections. If you can, avoid people with colds or other infections. If you think you are getting a cold or other infection, check with your doctor.
Grapefruits and grapefruit juice may increase the effects of sirolimus by increasing the amount of this medicine in your body. You should not eat grapefruit or drink grapefruit juice while you taking this medicine.
Sirolimus may cause you to have a greater risk for getting skin cancer. When you begin taking this medicine:
·Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
Side Effects of Sirolimus:
Also, because of the way sirolimus acts on the body, there is a chance that it may cause effects that may not occur until years after the medicine is used. These delayed effects of taking siroimus may include certain types of cancer, such as lymphoma.
Check with your doctor or nurse immediately if any of the following side effects occur after you taking sirolimus:
Check with your doctor as soon as possible if any of the following side effects occur after you taking sirolimus.:
Other side effects of taking sirolimus may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:
|Certificate of Analysis||Rapamycin (Sirolimus) COA|
|Literature||Rapamycin (Sirolimus) literature|
|MSDS||Rapamycin (Sirolimus) MSDS|
|1.||Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N (2010) Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochim. Biophys. Acta 1804(3), 433–9.|
|2.||Abraham RT Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol 10:330-6 (1998). Read more: Click here!|
Copyright © 2020 - . All Rights Reserved