CAS No.: 221877-54-9   Request for quotation

Zotarolimus, tetrazole-containing macrocyclic immunosuppressant, known as ABT-578, is a noval analogue of rapamycin (sirolimus) that was designed to have a shorter in vivo half-life than rapamycin.

Zotarolimus was not genotoxic in the in vitro bacterial reverse mutation assay, the human peripheral lymphocyte chromosomal aberration assay, or the in vivo mouse micronucleus assay.

Zotarolimus Specification (Factory standard)

Appearance White crystalline powder   Standard Packing 10g/bag or per customer request
Purity (HPLC) > 98%   Inventory Normally we have Zotarolimus in stock
Solubility Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.    
Heavy metal < 20 ppm   Zotarolimus physical parameters
Total impurity (HPLC) < 2%   CAS No: 221877-54-9
Water < 3%   Formula C52H79N5O12
Isomer < 10%   Molecular Weight 966.2
      Synonym 42-(1-Tetrazolyl)rapamycin; A179578; ABT578; Endeavor; Resolute; ABT-578
      Structure Zotarolimus 
Certificate of Analysis Zotarolimus COA      
Literature Zotarolimus literature      
MSDS Zotarolimus MSDS      
1. Compositions, systems, and kits for administering zotarolimus and paclitaxel to blood vessel lumens. Burke S.E. et al. US Patent 7,357,942, 2008.
2. Zotarolimus, a novel sirolimus analogue with potent anti-proliferative activity on coronary smooth muscle cells and reduced potential for systemic immunosuppression Chen Y.W. et al. J. Cardiovasc. Pharmacol. 2007, 49, 228.

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